Jamal Mohamed College was founded in 1951, as an affiliated college to the university of Madras. It was established as a religious minority institution with the primary objective of providing higher education to the downtrodden and socially backward sections of the society in general and Muslim Minority in particular. Janab. M. Jamal Mohamed sahib and Janab. N.M. Khajamian Rowther of revered memory were the founding fathers of this institution. The college was inaugurated by Hon. Thiru. P.S. Kumarasamy Raja, the then Chief Minister of Madras with His Excellency, the Maharaja of Bhavanagar, the then Governor of Madras presiding over the function.

Over the period of 5 decades, the college was able to scale greater and greater heights and raise to the present status as a multi faculty institution  with 14 UG courses and 16 PG courses and Research Programmes in all the departments by promoting quality and excellence in higher education due to the sustained efforts and dedicated leadership given by the college management committee.

The college was awarded the coveted Five Star Status by NAAC, an autonomous body of UGC, during the Golden Jubilee Year.

The college was conferred with Autonomous Status by the UGC in the academic year 2004.